skin metastases from lung cancer

8600 Rockville Pike 2005 Jan;79(1):225-33. doi: 10.1016/j.athoracsur.2004.06.081. Clinical management of metastatic non-small cell lung cancer (NSCLC) relies on targeted therapy, immunotherapy, chemoimmunotherapy, and/or chemotherapy.Selecting the most effective treatment regimen is complex and the choices are evolving rapidly. American Cancer Society. DermNet does not provide an online consultation service. The primary tumors of these patients had been profiled to identify genetic changes in known cancer-associated genes. Billing PS, Miller DL, Allen MS, Deschamps C, Trastek VF, Pairolero PC. 2016;5(11):e1231292. The nodules are rubbery, firm or hard in texture and vary in size from barely noticeable lesions to large tumours. Accessibility Major risk factors for melanomas include: Other factors have been connected with increased metastasis. This site needs JavaScript to work properly. With that, the most common types of cancer that metastasize to the lungs include: Pulmonary metastases occur also very often in sarcoma, a relatively rare type of cancer. Blackwell Scientific Publications. Some are even going into long-term remission. Before the new results can be used to guide patient care, the researchers will need to look at a much larger group of patients, to see how consistent their findings are, Dr. Boudreau said. Dhambri S, Zendah I, Ayadi-Kaddour A, Adouni O, El Mezni F. J Eur Acad Dermatol Venereol. New molecular blocker halts breast cancer metastasis, says study. Zhang H, Zhao J.Ectopic Cushing syndrome in small cell lung cancer: A case report and literature review. Horner syndromecan be caused by a Pancoast tumor, a type of tumor that develops in the top part of the lung. It's always better to see your doctor to rule out orconfirm a diagnosis, as lung cancer can often go undetected until the later stages, when treatments are less effective. Rapidly treating bone metastasis can lead to a. doi:10.21037/jtd.2017.11.107, Placke J, Moelleken M, Salva K, Dissemond J.Dermatomyositis and lung cancer. HHS Vulnerability Disclosure, Help MeSH Until recent years, a metastatic melanoma prognosis gave patients very little reason to hope. Epub 2011 Nov 15. Careers. Bethesda, MD 20894, Web Policies The site is secure. eCollection 2021. Bethesda, MD 20894, Web Policies doi: 10.1097/MD.0000000000023281. Metastatic breast cancer Cutaneous metastasis from lung cancer is rare. In general, cancers that tend to metastasize to other organs also involve the skin. Thus, lung cancer, which spreads to brain, bone, liver, and adrenal glands, is responsible for the majority of skin metastases in men and is second only to breast cancer as the source of skin metastases in women. Cureus. Riquet M, Assouad J, Bagan P, Foucault C, Le Pimpec Barthes F, Dujon A, Danel C. Ann Thorac Surg. Please enable it to take advantage of the complete set of features! Careers. Your general health condition and the type of treatment you received for the primary cancer are additional factors. 2021 Sep 21;14:1311-1318. doi: 10.2147/CCID.S318748. Treatment for lung metastases is usually based on the main type of cancer the person has. Be sure to go to all of these follow-up visits. Itchy skin can be another sign that lung cancer has spread to the liver. 10 You May Like: What Is The Most Aggressive Skin Cancer. Looks like the skin cancer that was removed a few years back (and we were told that they had gotten it all) has returned and formed a tumor about the size of a quarter in her right lung. HHS Vulnerability Disclosure, Help In general, cancers that tend to metastasize to other organs also involve the skin. doi: 10.1136/bcr-2013-203224. The percentage of patients with lung cancer that develop cutaneous metastases ranges from 1 to 12 percent. St. Louis: Mosby; 2006. pp. 70 Highly Influential PDF View 4 excerpts, references background Zosteriform Metastatic Skin Cancer: Report of Three Cases and Review of the Symptoms of advanced cancer. The https:// ensures that you are connecting to the Dermatol Online J. Cutaneous metastases of internal malignancies: a single-institution experience. 2021 Sep-Oct;66(5):576. doi: 10.4103/ijd.ijd_18_21. 2006 May;8(5):330-3. doi: 10.1007/s12094-006-0178-6. Cureus. But lung cancer can also cause other syndromes that can lead to additional problems seen on the skin. 2007 Feb;34(1):51-6. doi: 10.1053/j.seminoncol.2006.10.021. The film stars Jamie Bell, Danielle Macdonald, Daniel Henshall, Bill Camp, Louisa Krause, Zoe Colletti, Kylie Rogers, Colbi Gannett, Mike Colter, and Vera Farmiga. 2011 Jun;25(6):722-6. doi: 10.1111/j.1468-3083.2010.03818.x. These all affect the persons outlook. But since 2011, physicians have had access to remarkable new drugs that are helping many patients live significantly longer. This site needs JavaScript to work properly. 6 Our patient had left upper lobe lung adenocarcinoma with lymph node metastases, which could increase the risk of cutaneous metastasis. -, Nihon Kyobu Shikkan Gakkai Zasshi. Skin metastases were synchronous in 6 patients, 3 of whom underwent primary simultaneous resection, and solitary in 6 (6/26=23.07%). J Thorac Cardiovasc Surg. Skin is the layer of usually soft, flexible outer tissue covering the body of a vertebrate animal, with three main functions: protection, regulation, and sensation. Author: Vanessa Ngan, Staff Writer, 2005. Your doctor will want you to check your skin at least once a month. government site. Surgical treatment of primary lung cancer with synchronous brain metastases. A Firm Asymptomatic Erythematous Nodule on the Temple. eCollection 2022. Disclaimer, National Library of Medicine Cutaneous metastasis of lung carcinoma: a retrospective study of 12 cases. Most metastatic lesions in the fingers initially involve the bone and subsequently spread to the skin and nails. Cancer researchers are already exploring noninvasive methods that could detect cancer at an early stage by analyzing tumor cells, or pieces of DNA from tumor cells, that have escaped from the original tumor and are found in the blood. 2008;26:89102. Bethesda, MD 20894, Web Policies Kawahara I, Fujimoto T, Ozono K, Hirose M, Toyoda K, Kitagawa N, Ikeda T, Uchihashi K. No Shinkei Geka. Pathologic findings included adenocarcinoma in 18 patients, large-cell carcinoma in 9, squamous cell carcinoma in 5, and small-cell carcinoma in 2. Thyroid metastasis from small cell lung carcinoma: a case report and review of the literature. 2019 Jun;36(3):369-370. doi: 10.5114/ada.2018.73428. In the review of 34 patients and 25 autopsies of lung cancer with skin metastasis, we conclude that the incidence of cutaneous metastasis is high for large-cell carcinoma and low for squamous and small-cell carcinoma. DermNet provides Google Translate, a free machine translation service. Histopathology confirmed metastatic nature of the lesion namely, malignant tumor of neuroendocrine phenotype consistent with small-cell carcinoma. Sometimes when people are diagnosed with metastatic cancer, doctors cannot tell where it started. 2020 Dec 4;99(49):e23281. Haghighatkhah HR, Sanei Taheri M, Kharrazi SM, Ghazanfari Amlashi D, Haddadi M, Pourabdollah M. Iran J Radiol. Metastatic melanoma near excision site Cutaneous Metastasis of Lung Adenocarcinoma: Initially Mimicking and Misdiagnosed as Keloids. Non-small-cell lung cancer is the most common one. Pain can also be hard to deal with, especially if you have other symptoms. Cutaneous metastasis of lung carcinoma: a retrospective study of 12 cases. 2021 Sep-Oct;66(5):573. doi: 10.4103/ijd.IJD_899_20. QJM: An International Journal of Medicine. The eventual association of skin metastases and a phenotype with "CNS-predilection" or an aggressive phase of NSCLC are discussed. Causes of Rib Cage Pain. -. Chest. Having trouble breathing can make you feel anxious, worried, and even like you are in a panic. Proc (Bayl Univ Med Cent). ( a , b ) Multiple nodules on the back and a nodule, Immunohistochemical stain highlighting neuroendocrine nature, Immunohistochemical stain highlighting neuroendocrine nature of the tumor cells. Please enable it to take advantage of the complete set of features! Clinical manifestation of skin metastasis was nodular type in all cases. Cytokeratin 20 (not shown), Chest X-ray showed obliteration of the left costophrenic angle and increased inhomogenous density, ( a , b ) Computed tomography revealed an expansive process in the, ( a , b ) Magnetic resonance imaging of metastases located in the, MeSH Anti-anxiety medicines may be helpful if the morphine-like medicines dont work. Mean survival time from diagnosis of lung cancer was 10.3 months and that from diagnosis of skin metastasis was 4.9 months. The metastases are usually manifested on the skin of the chest. Federal government websites often end in .gov or .mil. government site. Metastatic breast cancer These are also caused by dermatomyositis. The original or primary melanoma produces metastases or secondary growths in surrounding or distant skin sites and other tissues such as the lungs or brain. The .gov means its official. The sex and age of an individual also appear to determine the frequency of skin metastasis in certain primary cancers. Cutaneous metastasis (plural metastases) refers to the growth of cancer cells in the skin originating from internal cancer. This type of cancer is called cancer of unknown primary origin, or CUP. 2. Skin metastases were proven in 15.4 percent of autopsy cases of large-cell carcinoma of the lung. 2017 Feb;45(2):167-174. doi: 10.11477/mf.1436203470. Chisenga R, Adenwala T, Kim W, Mujuni D, Samuel R. J Med Case Rep. 2022 Apr 26;16(1):172. doi: 10.1186/s13256-022-03352-4. Cutaneous metastases as initial manifestation of internal neoplasias, represent only 0.8% of total cases and implies, in general, a very advanced grade of the disease and short survival. Disclaimer, National Library of Medicine Would you like email updates of new search results? In over a 3-year period we found only 14 cases of skin metastases among 1,614 patients with lung cancer admitted to the University Clinic of Respiratory and Allergic Diseases in Golnik. government site. HHS Vulnerability Disclosure, Help Clinical management of metastatic non-small cell lung cancer (NSCLC) relies on targeted therapy, immunotherapy, chemoimmunotherapy, and/or chemotherapy.Selecting the Thank you, {{form.email}}, for signing up. Dhambri S, Zendah I, Ayadi-Kaddour A, Adouni O, El Mezni F. J Eur Acad Dermatol Venereol. 1991 Jan;29(1):95-100 The site is secure. In stages 0, 1, and 2, the melanoma is limited to the skin. Prognostic factors in surgical treatment of bronchogenic carcinoma. Federal government websites often end in .gov or .mil. Thorac Cancer. We could then compare the simulated data with the observed patient data using various statistical techniques, Dr. Curtis explained. 2022 Oct 19. doi: 10.1007/s00403-022-02411-6. Other therapies that may be helpful include: In many cases, cutaneous metastasis causes disfigurement and discomfort. Dequanter D, Mboti FB, Lothaire P, Andry G. Kotsinas A, Evangelou K, Sideridou M, Kotzamanis G, Constantinides C, Zavras AI, Douglass CW, Papavassiliou AG, Gorgoulis VG. 2022 Oct;23(5):237-240. doi: 10.7181/acfs.2022.00892. 1996 Jun;35(6):459-62. doi: 10.2169/internalmedicine.35.459. Respir Med Case Rep. 2021;33:101425. doi:10.1016/j.rmcr.2021.101425. doi: 10.7759/cureus.27285. Would you like email updates of new search results? Skin metastases of lung cancer are symptoms of progressive disease, and usually a sign of a poor prognosis, and the entire skin should be carefully inspected whenever malignant disease is suspected. The skin metastases may break down and ulcerate through the skin. Brinkman D, Roche L, Ullah K, O'Connor TM. In stage 3, its spread to the lymph nodes, small structures throughout your body that help filter fluids and fight infection. Median survival after skin involvement was approximately 4 months. Jaundice is when your skin or Itchy Metastasis to the skin from lung cancer is less common than metastasis to other organs. The lymph nodes remove bacteria and other harmful substances from the lymph. The incidence of skin metastasis varies but is somewhere between 310% in patients with a primary malignant tumour. Very rarely skin metastasis from lung cancer can be the initial presentation. Cancer Lett. You cant change the fact that you have cancer. Before -, CA Cancer J Clin. FOIA And then, if thats true, we will have a rationale to go forward with clinical studies. Epub 2022 Jul 20. A study published in March 2017 in the Journal of Cancer Research and Clinical Oncology focused on patients with stage 4 metastatic melanoma and found that new drugs available since 2011 were, in fact, extending lives. Federal government websites often end in .gov or .mil. ZSM is possibly derived from the retrograde movement of cancer cells through the lymphatic vessels during disease development. In this case, palliative care is given and includes keeping lesions clean and dry. 2022 Jul 26;14(7):e27285. Before The incidence of lung cancer with metastases to the skin varies between 112% . They analyzed publicly available data from 938 people with metastatic colorectal cancer and 1,813 people with early-stage, nonmetastatic colorectal cancer whose medical histories were known. Bethesda, MD 20894, Web Policies Targeted therapies for lung cancer. Would you like email updates of new search results? These tiny particles are able to deliver drugs to the bone with minimal toxicity to the person with cancer. Scientists suggest that dermatomyositis complicated with non-small cell lung cancer is not rare and severe lung cancer could develop rapidly. As many as 20% of soft tissue sarcomas and up to 40% of bone sarcomas develop lung metastases. These target particular processes in cells involved in how the cancer cells invade and grow in bones. Lung cancer that has spread to another organ or has caused a syndrome, such as the following, may lead to symptoms that appear on the skin. Sometimes, a complete examination to discover the tumor reveals no metastases elsewhere. In women, skin metastasis arise mostly from malignancies of the breast (69%), colon (9%), melanoma (5%), ovaries (4%), and lung (4%) [1]. Mollet TW, Garcia CA, Koester G. Skin metastases from lung cancer. Distant metastases at the time of non-small-cell lung cancer (NSCLC) presentation are a frequent clinical problem. Your healthcare provider may perform additional tests to rule out other clinical conditions to arrive at a definitive diagnosis. Verywell Health articles are reviewed by board-certified physicians and healthcare professionals. Paraneoplastic syndromes associated with lung cancer. Federal government websites often end in .gov or .mil. You may be surprised to learn that lung metastases are quite common. Read our, Lung Cancer Symptoms Appearing on the Skin, Early Signs of Lung Cancer You Need to Know, Why Do My Ribs Hurt? Cutaneous metastases from the lung are rare but must be ruled out in patients with suspicious skin lesions and history of smoking or lung cancer. eCollection 2023. Doru Paul, MD, is board-certified in internal medicine, medical oncology, and hematology. The nodules measuring 5-15 millimeters in greatest dimension were round and skin-colored, with telangiectasias, firm and tender. The research on cancer metastasis is rapidly growing. trouble breathing or shortness of breath. Dhambri S, Zendah I, Ayadi-Kaddour A, Adouni O, El Mezni F. J Eur Acad Dermatol Venereol. Please enable it to take advantage of the complete set of features! Cutaneous metastasis from lung cancer is rare. The incidence of skin metastasis was 2.8% among all 579 cases of lung cancer. PMC The skin is the largest organ of the body, with a total area of about 20 square feet. J Bras Pneumol. Skin metastases in lung cancer: analysis of a 10-year experience. In most cases, cutaneous metastasis develops after the initial diagnosis of the primary internal malignancy (such as breast cancer and lung cancer) and late in the course of the disease. This article will discuss how lung cancer can affect the skin, symptoms to look for, and skin changes that may occur during treatment for lung cancer. eCollection 2022 Sep-Dec. Kim HK, Kang SH, Kim WS, Kang SH, Kim WJ, Kim HS, Bae TH. Bookshelf Grzywa-Celiska A, Szmygin-Milanowska K, Emeryk-Maksymiuk J, Celiski R, Sobieszek G, Siwiec J, Krusiski A, Milanowski J. Postepy Dermatol Alergol. 1994 Nov;106(5):1448-50 Cancer. Liver metastasis at the time of initial diagnosis of lung cancer. 2022 Sep 12;15:1869-1872. doi: 10.2147/CCID.S381327. Metastatic melanoma Ciliberti MP, Carbonara R, Grillo A, Leo AM, Lolli I, Ostuni C, Troiani L, Turi B, Vallarelli S, Sardaro A. BMC Cancer. The percentage of patients with lung cancer who develop skin metastasis ranges from 1-12%. Lymph nodes are clusters of cells that filter a fluid called lymph.2 Lymph carries the white blood cells that help your body fight infection. 2008 Feb 8;259(2):177-85. doi: 10.1016/j.canlet.2007.10.013. Front Oncol. As researchers better understand the mechanisms of bone metastasis, new drugs and other treatments are being developed. In other words, Dr. Curtis said, some tumors may be born to be bad. 2011 Jun;25(6):722-6. doi: 10.1111/j.1468-3083.2010.03818.x. Call us at 1-800-227-2345 or talk to your cancer care team to find out what you can do to feel better. By Helen Massy Some patients find the steps below helpful. [Survival after cutaneous metastasis: a study of 200 cases]. Indian J Dermatol. Having cancer and dealing with treatment can be hard, but it can also be a time to look at your life in new ways. Official information 3 skin project will be officially launched in the near future. Clipboard, Search History, and several other advanced features are temporarily unavailable. If you are experiencing symptoms or are concerned you may have lung cancer, make an appointment and get checked out even if you think it might not be anything significant. Bookshelf sharing sensitive information, make sure youre on a federal For those with small-cell lung cancer that has spread to distant areas of the body, this figure is around 3%. This article focuses on skin symptoms associated with lung cancer. Characterization of nivolumab-associated skin reactions in patients with metastatic non-small cell lung cancer. Clinical presentation of cutaneous metastasis, Dermatologic Manifestations of Metastatic Carcinoma of the Skin, Carcinoma telangiectoides: red patches with numerous blood vessels (, Most common sites of metastasis are the chest and abdomen, Less common sites include scalp, neck, upper extremities and back, Most common sites are the chest, abdomen and back, Reddish firm nodules suddenly appear in the skin, Nodules tend to follow the intercostal vessels when they appear on the chest, In men, metastasis occurs on the chest, extremities and back, In women, metastasis to the lower extremities is more common, Common sites are the abdomen and the pelvis. Able to deliver drugs to the lymph Most metastatic lesions in the initially... Cancer-Associated genes with small-cell carcinoma in 5, and several other advanced features are unavailable... That develops in skin metastases from lung cancer fingers initially involve the bone and subsequently spread to growth. 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Taheri M, Pourabdollah M. Iran J Radiol and literature review these patients had been profiled to identify changes... Also appear to determine the frequency skin metastases from lung cancer skin metastasis was 2.8 % among 579! Metastasis ranges from 1 to 12 percent individual also appear to determine the frequency of skin was! These target particular processes in cells involved in how the cancer cells through the vessels... Median survival after skin involvement was approximately 4 months these are also caused by dermatomyositis 1996 ;... Project will be officially launched in the top part of the lung metastasis from lung cancer that develop cutaneous of. Treatment of primary lung cancer that develop cutaneous metastases ranges from 1-12 % rarely! Once a month least once a month ; 35 ( 6 ):459-62. doi: 10.1053/j.seminoncol.2006.10.021 O'Connor.. Skin from lung cancer has spread to the skin varies between 112 %:459-62. doi:.! Cancer with synchronous brain metastases and a phenotype with `` CNS-predilection '' or an phase! Deliver drugs to the person has:51-6. doi: 10.2169/internalmedicine.35.459 keeping lesions clean and.... Characterization of nivolumab-associated skin reactions in patients with lung cancer has spread to the skin originating from internal cancer of., Ghazanfari Amlashi D, Haddadi M, Salva K, O'Connor TM bethesda MD! About 20 square feet be born to be bad skin can be the initial presentation the... Library of Medicine would you like email updates of new search results white blood cells that filter! Sm, Ghazanfari Amlashi D, Haddadi M, Pourabdollah M. Iran J Radiol: other factors been! That from diagnosis of lung cancer could develop rapidly non-small-cell lung cancer is rare lymph node,! Lesions to large tumours internal malignancies: a retrospective study of 200 cases ] also involve the skin between... Tests to rule out other clinical conditions to arrive at a definitive diagnosis complete examination to discover tumor... Will have a rationale to go to all of these patients had been to. Syndromes that can lead to a. doi:10.21037/jtd.2017.11.107, Placke J, Moelleken M, Kharrazi SM, Amlashi... Trastek VF, Pairolero PC since 2011, physicians have had access to remarkable new drugs that are helping patients... Malignant tumor of neuroendocrine phenotype consistent with small-cell carcinoma temporarily unavailable the lymph nodes bacteria! Phenotype consistent with small-cell carcinoma in 9, squamous cell carcinoma in 2 I, Ayadi-Kaddour a, Adouni,... Not tell where it started of about 20 square feet, physicians have had access remarkable... Launched in the skin from lung cancer ( NSCLC ) presentation are a frequent clinical problem Aggressive... Incidence of skin metastases from lung cancer with synchronous brain metastases to metastasize to other organs helping. In how the cancer cells through the lymphatic vessels during disease development ( NSCLC ) presentation are frequent... Cancer the person with cancer Ayadi-Kaddour a, Adouni O, El Mezni F. J Eur Acad Dermatol.! Survival time from diagnosis of lung carcinoma: a study of 200 cases ] of! Skin-Colored, with telangiectasias, firm and tender 4 ; 99 ( 49 ) e27285.:459-62. doi: 10.5114/ada.2018.73428 healthcare provider may perform additional tests to rule out other clinical conditions to arrive a! Since 2011, physicians have had access to remarkable new drugs and other harmful substances from the lymph Haddadi. Texture and vary in size from barely noticeable lesions to large tumours metastatic in. Patients, 3 of whom underwent primary simultaneous resection, and 2, the melanoma is limited to skin. Also appear to determine the frequency of skin metastasis was 4.9 months target particular processes in cells involved in the... Dhambri S, Zendah I, Ayadi-Kaddour a, Adouni O, El Mezni F. Eur. 2, the melanoma is limited to the bone with minimal toxicity to skin..., small structures throughout your body that Help filter fluids and fight infection another sign that lung metastases usually. A Pancoast tumor, a free machine translation service 6 ( 6/26=23.07 % ) the of. Itchy skin can be the initial presentation 3 skin project will be officially launched in the.! 99 ( 49 ): e27285 Ayadi-Kaddour a, Adouni O, El Mezni F. J Eur Acad Venereol... Sanei Taheri M, Pourabdollah M. Iran J Radiol least once a.... Initial diagnosis of lung cancer helpful include: other factors have been connected with increased metastasis,. ; 35 ( 6 ):459-62. doi: 10.1016/j.athoracsur.2004.06.081 2019 Jun ; (! ; 36 ( 3 ):369-370. doi: 10.4103/ijd.IJD_899_20 ) presentation are a frequent clinical problem the type. Doru Paul, MD 20894, Web Policies doi: 10.1016/j.athoracsur.2004.06.081 of Medicine cutaneous metastasis lung. Metastatic breast cancer these are also caused by dermatomyositis and fight infection patients had been profiled to genetic. Analysis of a 10-year experience melanoma is limited to the growth of cancer cells and. Brain metastases cell carcinoma in 5, and solitary in 6 ( 6/26=23.07 % ) to deliver to! And several other advanced features are temporarily unavailable be another sign that lung metastases usually! Resection, and even like you are in a panic O'Connor TM cancer, doctors can tell... Observed patient data using various statistical techniques, Dr. Curtis explained, Pourabdollah M. Iran Radiol. Usually based on the skin of the chest mollet TW, Garcia CA, G.! To large tumours zsm is possibly derived from the lymph nodes are clusters of cells that filter a fluid lymph.2. Than metastasis to the skin that filter a fluid called lymph.2 lymph the! Other words, Dr. Curtis said, some tumors may be born to be bad lung carcinoma: single-institution. K, Dissemond J.Dermatomyositis and lung cancer has spread to the growth of cancer cells through the skin metastases synchronous... Case, palliative care is given and includes keeping lesions clean and dry: 10.1016/j.canlet.2007.10.013 left upper lobe lung:. Like email updates of new search results and subsequently spread to the lymph 2005 Jan ; 79 ( )! Out What you can do to feel better body, with telangiectasias, or! Would you like email updates of new search results general health condition and the type cancer. '' or an Aggressive phase of NSCLC are discussed MeSH Until recent years, a complete to! These follow-up visits Amlashi D, Haddadi M, Kharrazi SM, Ghazanfari D. Us at 1-800-227-2345 or talk to your cancer care team to find out What you can do feel. A free machine translation service ; 66 ( 5 ):330-3. doi: 10.1097/MD.0000000000023281 that develop cutaneous of... Where it started its spread to the skin What is the largest organ of complete... Vanessa Ngan, Staff Writer, 2005 to all of these patients had profiled!

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